Dutasteride, however, is a so-called dual inhibitor with both 5α-R1 and 5α-R2 inhibition. IC50 for 5α-R1 is 7 nM but 6 nM for 5α-R2. As mentioned above, it reduces DHT > 90% overall, or precisely % and for intraprostatic DHT the reduction is 97-99%. Dutasteride has also been found to inhibit 5α-R3, in vitro, with IC50= nM.  The 2,5-difluorophenyl side chain on the D-ring of the compound shows significant lipophilic features and as increased lipophilicity enhances the potency of the compounds binding at pocket site, its potency is much greater than of finasteride. 
In 2005, Joanna was featured in a one-hour documentary called Supersize She, which was also broadcast in the US on The Learning Channel. The show followed her training leading up to the 2004 Ms. Olympia contest. The documentary talks about her life, her parents' feelings about her decision to become a bodybuilder and nude model, her physical changes, dieting requirements, and her passion for bodybuilding as well as all the sacrifices she made to become a professional bodybuilder. The documentary was a huge success in the UK and in the US.