As an example, should you choose to run a cycle that includes both Dianabol and Anavar, you will need to be extremely careful when it comes to overlapping them. The two are both hepatotoxic, which means they will cause liver damage. You will need to consider this carefully when it comes to choosing cycle lengths. If you take Dianabol for four weeks at the beginning of your cycle, then make the switch to Anavar, you should limit your Anavar use to four weeks, as well. This reduces your entire cycle time to eight weeks, which helps to alleviate some of the risk of liver damage.
The formation of gallstones is probably one of the major causes of blockage in the bile ducts. This also results in the formation of stones of different sizes in the gallbladder that create a blockage in the common bile duct present at the liver base. In the event the duct continues to stay blocked waste matter starts getting collected in the bloodstream as well as the system of the bile duct. You may also develop a severe infection known as ascending cholangitis, if bacteria accumulates with the blockage and retreats into the liver. If the gallstone stops between the gallbladder and the common bile duct, an infection known as cholecystitis could result.
Endocrine side effects have included inhibition of endogenous testosterone release by means of feedback inhibition of pituitary luteinizing hormone (LH). Large doses of exogenous anabolic steroids may suppress spermatogenesis through inhibition of pituitary follicle stimulating hormone (FSH). The androgenic activity of anabolic steroids may decrease levels of thyroxin-binding globulin and result in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged and there is no clinical evidence of thyroid dysfunction. [ Ref ]